The Tennessee Titans went to Houston and upset the AFC South-leading Texans 32-27. Will Levis threw for 278 yards with two touchdowns and an interception. He was also sacked 8 times. Calvin Ridley had another big game with five catches for 93 yards. Tony Pollard ran for 119 yards and a touchdown. For the Texans, C.J. Stroud struggled throwing for just 247 yards with two touchdowns and two interceptions. Nico Collins managed a solid day with five catches for 92 yards and a touchdown. The Texans could not get anything going on the ground. Joe Mixon had 14 carries for just 22 yards. The Titans host the Washington Commanders in week 13 while the Texans travel to Jacksonville to play the Jaguars.

Anthony Richardson struggled in the Indianapolis Colts 24-6 loss to the Detroit Lions. Richardson completed just 11 of 28 passes for 172 yards. He did add 61 yards on the ground. Michael Pittman led the Colts receivers with six catches for 96 yards. The Colts take on the New England Patriots on Sunday.

The Jacksonville Jaguars had their bye in week 12.

AFC South Standings Week 12

Houston Texans 7-5

Indianapolis Colts 5-7

Tennessee Titans 3-8

Jacksonville Jaguars 2-9